The Best Weed Strains for Depression

Rates of diagnosed depression have been steadily rising both here in the UK and globally for the past few decades. In fact, according to the World Health Organization, depression is now the leading cause of disability worldwide. That’s kind of depressing in and of itself.

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To add insult to injury, they may not even be that effective—a recent study found that 10%–30% of patients with major depression do not respond to typical antidepressant medications. Again, pretty depressing stuff.

But it’s not all doom and gloom, folks.

Medical cannabis became a legal treatment option for depression in the UK in 2018, and there has been an increasing amount of research into its potential benefits for mental health conditions.

So, if you’re one of the many people who struggle with depression and are interested in exploring alternative options, read on to discover some of the best weed strains for depression that may provide relief for your symptoms.

different weed strains Key Takeaways

• Individual Responses Vary: Each person may experience the effects of cannabis strains differently due to factors such as personal tolerance, metabolism, genetics, and the specific growing conditions of the plant.
• Consult Specialists: It’s crucial to consult with a specialist at a private medical cannabis clinic to find the most suitable strain and dosage for your specific needs. Expert guidance can minimize risks and enhance the benefits.
• Variety of Consumption Methods: Cannabis can be consumed in various ways, including vaping, edibles, tinctures, and topicals. Each method has its own set of advantages and disadvantages, so it’s important to find what works best for you.
• Hybrid Strains Are Versatile: Hybrid strains combine the effects of both Indica and Sativa strains, potentially offering balanced effects that cater to a broad range of needs, from relaxation to increased energy.
• Monitor and Adjust: Pay close attention to your body’s response to different strains and methods of consumption. Use this feedback to make informed choices and adjustments for optimal relief from depression symptoms.

The science behind cannabis and depression

Before we dive into specific weed strains, let’s take a look at the science behind how cannabis may help with depression. The plant contains over 110 different compounds called cannabinoids, but the two most intriguing for depression sufferers are tetrahydrocannabinol (THC) and cannabidiol (CBD).

These compounds can interact with the endocannabinoid system (ECS).

How?

Well, the name might have given it away, but the ECS is actually the largest neurotransmitter system in the body, consisting of a complex network of receptors and molecules (endocannabinoids).

See the similarity in the words cannabinoids and endocannabinoids?

That’s because the plant-based compounds mimic those produced naturally by our bodies. They are also able to interact with the ECS, and modulate the activity of the neurotransmitters involved in regulating mood, stress, pain, sleep, inflammation, ect.

THC for depression explained

THC is the psychoactive compound in cannabis that produces the “high” feeling. It’s also known to have mood-altering effects. We have all heard of the euphoria and joy that can come from lighting up a bifta, but this is now backed up by scientific evidence.

THC interacts directly with the CB1 receptors in the brain, which regulate mood and emotions, as well as pain perception, appetite, and memory. In low doses, it can reduce stress and anxiety, leading to a feeling of relaxation and well-being.

In higher doses, however, THC may have the opposite effect and cause anxiety or paranoia. So, it’s important to find a strain with the right balance when using weed for depression relief. More on this further down.

Studies have shown that THC can also interact with the brain’s reward system and increase levels of dopamine, a neurotransmitter associated with feelings of pleasure and motivation. This is why many people report an uplift in mood after using weed for depression relief.

But its effects on mood may go deeper than just boosting dopamine levels. THC has also been found to increase the production of endorphins, which are chemicals that promote feelings of happiness and well-being.

CBD for depression explained

On the other hand, it does not produce any psychoactive effects or ‘high’, but is believed to have powerful anti-anxiety and antidepressant properties. CBD weakly binds to the CB2 receptors in the ECS, which regulate inflammation, the immune response, and pain perception. It also interacts with other receptors and channels in the brain, such as the serotonin 5-HT1a receptor, which plays a role in mood regulation, and by increasing levels of the ‘bliss molecule’ anandamide (one of our endocannabinoids), a neurotransmitter associated with feelings of joy and happiness.